Streptococcal plasminogen activator, triggers the activation of the human contact system. Activation of contact system factors at the surface of the Streptococcus pyogenes serotype M49 is dependent on streptokinase and plasminogen. Our results also show that secreted streptokinase is an efficient contact system activator, independent from a contact surface. This results in the processing of high-m

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Karyotic cell nucleus and endomembrane system as per the chimeric model. The key event in the origin of the eukaryotic cell is postulated to be a symbiotic association between a gram-negative eubacterium (from the proteobacteria-1 group) and likely an "eocyte" archaebacterium. This association led to the loss of the outer membrane from the gram-negative bacterium (not shown). As the membrane of th

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Distinction within prokaryotes, formingthe primary taxonomic division within them, which is supported by both molecular sequence data and morphological features, is of the monoderm prokaryotes (Monodermata, i.e., those bounded by a single cell membrane) and the diderm prokaryotes (Didermata, i.e., those bounded by inner and outer cell membranes defining a periplasmic compartment). In that sense, b

Distinction within prokaryotes, formingthe primary taxonomic division within them, which is supported by both molecular sequence data and morphological features, is of the monoderm prokaryotes (Monodermata, i.e., those bounded by a single cell membrane) and the diderm prokaryotes (Didermata, i.e., those bounded by inner and outer cell membranes defining a periplasmic compartment). In that sense, b

System comprises four plasma proteins, circulating as zymogens in the bloodstream or being assembled on various cell types: the serine proteases factor XII (FXII), factor XI (FXI), and prekallikrein (PKK) and the nonenzymatic cofactor high-molecularweight kininogen (HK). The latter forms equimolar complexes with plasma kallikrein (PK) or FXI. The cascade is initiated upon contact to a negatively c

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