The small or large intestine is indicative of pneumatosis intestinalis. This situation refers to a necrotizing enterocolitis and can be considered as an indication for urgent surgery. Conservative management is recommended initially when these criteria are absent [50]. Badgwell et al. suggested better outcomes if it was possible to delay surgery until recovery from neutropenia [51]. General suppor
Ithout malignancy [53].Non anti-infectious agentsG-CSF and GM-CSFHaemopoietic growth factors, such as granulocyte colonystimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) have been assessed in several clinical trials [54,55]. The known effect of G-CSF and GM-CSF in increasing the number of circulating neutrophil granulocytes was the rationale for clinical stud
Ithout malignancy [53].Non anti-infectious agentsG-CSF and GM-CSFHaemopoietic growth factors, such as granulocyte colonystimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) have been assessed in several clinical trials [54,55]. The known effect of G-CSF and GM-CSF in increasing the number of circulating neutrophil granulocytes was the rationale for clinical stud
For removal in patients with septic shock, without an obvious other source of infection as the absence of local signs and symptoms are notoriously insensitive in the neutropenic host. In a cohort study of neutropenic cancer patients admitted to the ICU for severe sepsis or septic shock, Legrand et al. found that routinely removing indwelling catheters early on in patients with no other detectable
Nic sepsis that is unresponsive to conventional antimicrobial therapy. However, therapeutic administration of granulocyte transfusions in the neutropenic host with severe infection has no proven benefit. A cochrane database systematic review concludes that there is inconclusive evidence to support or refute the use of granulocyte transfusions [58]. More recently, in 30 severely ill neutropenic pat
On/collection or septic shock become evident in the later course.Vasopressor regimen during septic shockThe intestinal tract is a common site of infection in neutropenic patients. Neutropenic enterocolitis, also known as typhlitis is a life-threatening condition due to inflammatory/hemorrhagic/necrotizing involvement of the lower intestinal tract [50]. Criteria for neutropenic enterocolitis associ
On/collection or septic shock become evident in the later course.Vasopressor regimen during septic shockThe intestinal tract is a common site of infection in neutropenic patients. Neutropenic enterocolitis, also known as typhlitis is a life-threatening condition due to inflammatory/hemorrhagic/necrotizing involvement of the lower intestinal tract [50]. Criteria for neutropenic enterocolitis associ
S that have been suggested include delayed or prolonged neutropenia [46], and pneumonia [48]. G-CSF should be avoided in this context (cf infra).Zafrani and Azoulay BMC Infectious Diseases 2014, 14:512 http://www.biomedcentral.com/1471-2334/14/Page 5 ofCatheter removalDeciding when to remove CVC is a common problem in neutropenic patients in ICU. In patients with bacteremia due to Enterobacteriace