If the blockage is complete, it may cause a coronary heart assault (Myocardial Infarction or MI). Heart illness is the main trigger of loss of life in the United States. If a blockage happens in a leg artery, it causes Peripheral Vascular Disease (PVD) and may cause ache while walking referred to as intermittent claudication. If the blockage happens in a coronary artery, it causes chest ache (angina).