On the other hand, the GnRH antagonist protocol has a reduce danger of ovarian hyperstimulation syndrome (OHSS), which is a everyday living-threatening complication. The ensuing prediction of e.g. weak or hyper-response to ovarian hyperstimulation decides the protocol and dosage for ovarian hyperstimulation. It should really start off with response prediction by e.g. age, antral follicle rely and amount of anti-Müllerian hormone.