During early growth this spreading cell problems may lead to the eye and pores and skin abnormalities attribute of microphthalmia with linear skin flaws syndrome. Affected individuals could have the issue as a outcome of enlargement (hyperplasia) of the pituitary gland or progress of a noncancerous tumor in the gland (termed a pituitary adenoma). Some individuals with trisomy X have an extra X chromosome in only some of their cells.