Increases in nucleus accumbens ΔJunD expression (via viral vector-mediated gene transfer) or G9a expression (by way of pharmacological suggests) reduces, or with a large raise can even block, several of the neural and behavioral alterations that end result from persistent high-dose use of addictive drugs (i.e., the alterations mediated by ΔFosB). What can be accomplished about it? This suggests that promotion can be fought off piece by piece.