The presence of these ubiquitous steroids in a extensive selection of animals propose that intercourse hormones have an historic evolutionary record. Agnathans (jawless vertebrates) this kind of as lampreys do not make testosterone but in its place use androstenedione as a male sexual intercourse hormone. Advances in the Management of Testosterone Deficiency. Therapeutics and Clinical Risk Management. Jones TH, Saad F (December 2009).