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<title>The Meetingpoint at Slavyanski.net / corn81jaw / Upvoted</title>
<link>https://slavyanski.net/sb2020</link>
<description>Your Source for Social News and Networking</description>
<pubDate>Thu, 27 Aug 2020 23:49:14 +0000</pubDate>
<language>en</language>
<item>
	<title><![CDATA[T assays were conducted, and the mean percent relative activity is]]></title>
	<link>https://slavyanski.net/sb2020/story.php?title=t-assays-were-conducted-and-the-mean-percent-relative-activity-is-9</link>
	<source url="https://slavyanski.net/sb2020/story.php?title=t-assays-were-conducted-and-the-mean-percent-relative-activity-is-9"><![CDATA[T assays were conducted, and the mean percent relative activity is]]></source>
	<description><![CDATA[T assays were conducted, and the mean percent relative activity is reported (see text). A dose response from a single assay of the three is presented here as representative data. e Representative nonconstrained dose?response curves of ABP 501 (red), adalimumab (US) (black), and adalimumab (EU) (blue) showing binding to FcRn. Each point is a mean of three replicates ?standard deviation. Adalimumab  ]]></description>
	<pubDate>Thu, 27 Aug 2020 23:49:14 +0000</pubDate>
	<author>corn81jaw</author>
	<category>News</category>
	<votes>1</votes>
	<guid>https://slavyanski.net/sb2020/story.php?title=t-assays-were-conducted-and-the-mean-percent-relative-activity-is-9</guid>
</item>

<item>
	<title><![CDATA[Certolizumab is reduced in Crohn's disease relative to the efficacy]]></title>
	<link>https://slavyanski.net/sb2020/story.php?title=certolizumab-is-reduced-in-crohns-disease-relative-to-the-efficacy-8</link>
	<source url="https://slavyanski.net/sb2020/story.php?title=certolizumab-is-reduced-in-crohns-disease-relative-to-the-efficacy-8"><![CDATA[Certolizumab is reduced in Crohn's disease relative to the efficacy]]></source>
	<description><![CDATA[Certolizumab is reduced in Crohn's disease relative to the efficacy observed with adalimumab [24, 25], which suggests that Fc-mediated effector functions may be important. Binding of mAbs to FcRn affects clearance, so a similarity assessment of biosimilars should also include sensitive methods to assess binding to FcRn. ABP 501 was shown to have similar binding to FcRn as compared with adalimumab. ]]></description>
	<pubDate>Thu, 27 Aug 2020 23:04:26 +0000</pubDate>
	<author>corn81jaw</author>
	<category>News</category>
	<votes>1</votes>
	<guid>https://slavyanski.net/sb2020/story.php?title=certolizumab-is-reduced-in-crohns-disease-relative-to-the-efficacy-8</guid>
</item>

<item>
	<title><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity]]></title>
	<link>https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-8</link>
	<source url="https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-8"><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity]]></source>
	<description><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity to clinical efficacy is unclear, it is important to characterize all activities of the candidate mAb, especially those that can be affected by differences in post-translational modifications, such as glycosylation. The ability of ABP 501 to induce ADCC was assessed using MT-3 cells as target cells, and NK-92M1 cells s ]]></description>
	<pubDate>Wed, 26 Aug 2020 21:39:13 +0000</pubDate>
	<author>corn81jaw</author>
	<category>News</category>
	<votes>1</votes>
	<guid>https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-8</guid>
</item>

<item>
	<title><![CDATA[Functions in order to finely control the immune response in vivo.]]></title>
	<link>https://slavyanski.net/sb2020/story.php?title=functions-in-order-to-finely-control-the-immune-response-in-vivo--7</link>
	<source url="https://slavyanski.net/sb2020/story.php?title=functions-in-order-to-finely-control-the-immune-response-in-vivo--7"><![CDATA[Functions in order to finely control the immune response in vivo.]]></source>
	<description><![CDATA[Functions in order to finely control the immune response in vivo. Among its cellular functions, TNFa is able to induce cytokines, chemokines, proliferation, and also cell death. The induction of pro-inflammatory versus death signals depends upon the molecular context of the responding cell, and specifically whether NFjB is involved [8]. Adding to the complexity of signaling, it is also reported th ]]></description>
	<pubDate>Mon, 24 Aug 2020 19:43:46 +0000</pubDate>
	<author>corn81jaw</author>
	<category></category>
	<votes>1</votes>
	<guid>https://slavyanski.net/sb2020/story.php?title=functions-in-order-to-finely-control-the-immune-response-in-vivo--7</guid>
</item>

<item>
	<title><![CDATA[Functions in order to finely control the immune response in vivo.]]></title>
	<link>https://slavyanski.net/sb2020/story.php?title=functions-in-order-to-finely-control-the-immune-response-in-vivo--7</link>
	<source url="https://slavyanski.net/sb2020/story.php?title=functions-in-order-to-finely-control-the-immune-response-in-vivo--7"><![CDATA[Functions in order to finely control the immune response in vivo.]]></source>
	<description><![CDATA[Functions in order to finely control the immune response in vivo. Among its cellular functions, TNFa is able to induce cytokines, chemokines, proliferation, and also cell death. The induction of pro-inflammatory versus death signals depends upon the molecular context of the responding cell, and specifically whether NFjB is involved [8]. Adding to the complexity of signaling, it is also reported th ]]></description>
	<pubDate>Mon, 24 Aug 2020 18:42:16 +0000</pubDate>
	<author>corn81jaw</author>
	<category></category>
	<votes>1</votes>
	<guid>https://slavyanski.net/sb2020/story.php?title=functions-in-order-to-finely-control-the-immune-response-in-vivo--7</guid>
</item>

<item>
	<title><![CDATA[Onstrated since all of the ABP 501 lots fell within the quality]]></title>
	<link>https://slavyanski.net/sb2020/story.php?title=onstrated-since-all-of-the-abp-501-lots-fell-within-the-quality-3</link>
	<source url="https://slavyanski.net/sb2020/story.php?title=onstrated-since-all-of-the-abp-501-lots-fell-within-the-quality-3"><![CDATA[Onstrated since all of the ABP 501 lots fell within the quality]]></source>
	<description><![CDATA[Onstrated since all of the ABP 501 lots fell within the quality range established based on the adalimumab (US) lots tested. Another mechanism for inducing cell death is the induction of CDC in cells expressing mbTNFa. A comparison of the CDC activity of ABP 501 to that of adalimumab (US) and adalimumab (EU) using MT-3 cells as target cells was conducted. Mean (three independent experiments) percen ]]></description>
	<pubDate>Thu, 20 Aug 2020 22:37:37 +0000</pubDate>
	<author>corn81jaw</author>
	<category>News</category>
	<votes>1</votes>
	<guid>https://slavyanski.net/sb2020/story.php?title=onstrated-since-all-of-the-abp-501-lots-fell-within-the-quality-3</guid>
</item>

<item>
	<title><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity]]></title>
	<link>https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-7</link>
	<source url="https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-7"><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity]]></source>
	<description><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity to clinical efficacy is unclear, it is important to characterize all activities of the candidate mAb, especially those that can be affected by differences in post-translational modifications, such as glycosylation. The ability of ABP 501 to induce ADCC was assessed using MT-3 cells as target cells, and NK-92M1 cells s ]]></description>
	<pubDate>Thu, 20 Aug 2020 21:52:46 +0000</pubDate>
	<author>corn81jaw</author>
	<category>News</category>
	<votes>1</votes>
	<guid>https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-7</guid>
</item>

<item>
	<title><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity]]></title>
	<link>https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-8</link>
	<source url="https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-8"><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity]]></source>
	<description><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity to clinical efficacy is unclear, it is important to characterize all activities of the candidate mAb, especially those that can be affected by differences in post-translational modifications, such as glycosylation. The ability of ABP 501 to induce ADCC was assessed using MT-3 cells as target cells, and NK-92M1 cells s ]]></description>
	<pubDate>Thu, 20 Aug 2020 21:52:15 +0000</pubDate>
	<author>corn81jaw</author>
	<category></category>
	<votes>1</votes>
	<guid>https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-8</guid>
</item>

<item>
	<title><![CDATA[T assays were conducted, and the mean percent relative activity is]]></title>
	<link>https://slavyanski.net/sb2020/story.php?title=t-assays-were-conducted-and-the-mean-percent-relative-activity-is-7</link>
	<source url="https://slavyanski.net/sb2020/story.php?title=t-assays-were-conducted-and-the-mean-percent-relative-activity-is-7"><![CDATA[T assays were conducted, and the mean percent relative activity is]]></source>
	<description><![CDATA[T assays were conducted, and the mean percent relative activity is reported (see text). A dose response from a single assay of the three is presented here as representative data. e Representative nonconstrained dose?response curves of ABP 501 (red), adalimumab (US) (black), and adalimumab (EU) (blue) showing binding to FcRn. Each point is a mean of three replicates ?standard deviation. Adalimumab  ]]></description>
	<pubDate>Wed, 19 Aug 2020 04:03:12 +0000</pubDate>
	<author>corn81jaw</author>
	<category>News</category>
	<votes>1</votes>
	<guid>https://slavyanski.net/sb2020/story.php?title=t-assays-were-conducted-and-the-mean-percent-relative-activity-is-7</guid>
</item>

<item>
	<title><![CDATA[Functions in order to finely control the immune response in vivo.]]></title>
	<link>https://slavyanski.net/sb2020/story.php?title=functions-in-order-to-finely-control-the-immune-response-in-vivo--9</link>
	<source url="https://slavyanski.net/sb2020/story.php?title=functions-in-order-to-finely-control-the-immune-response-in-vivo--9"><![CDATA[Functions in order to finely control the immune response in vivo.]]></source>
	<description><![CDATA[Functions in order to finely control the immune response in vivo. Among its cellular functions, TNFa is able to induce cytokines, chemokines, proliferation, and also cell death. The induction of pro-inflammatory versus death signals depends upon the molecular context of the responding cell, and specifically whether NFjB is involved [8]. Adding to the complexity of signaling, it is also reported th ]]></description>
	<pubDate>Wed, 19 Aug 2020 02:53:14 +0000</pubDate>
	<author>corn81jaw</author>
	<category></category>
	<votes>1</votes>
	<guid>https://slavyanski.net/sb2020/story.php?title=functions-in-order-to-finely-control-the-immune-response-in-vivo--9</guid>
</item>

<item>
	<title><![CDATA[Assessment of the bioactivity of adalimumab should include assessment of multiple]]></title>
	<link>https://slavyanski.net/sb2020/story.php?title=assessment-of-the-bioactivity-of-adalimumab-should-include-assessment-of-multiple-7</link>
	<source url="https://slavyanski.net/sb2020/story.php?title=assessment-of-the-bioactivity-of-adalimumab-should-include-assessment-of-multiple-7"><![CDATA[Assessment of the bioactivity of adalimumab should include assessment of multiple]]></source>
	<description><![CDATA[Assessment of the bioactivity of adalimumab should include assessment of multiple in vitro endpoints (NFjB-dependent and NFjB-independent) and should include binding to both soluble and transmembrane TNFa. ABP 501 has been shown to be similar to adalimumab in its ability to neutralize TNFa-induced caspase activation, chemokine production, and cytotoxicity, functions inclusive of both NFjB-dependen ]]></description>
	<pubDate>Wed, 19 Aug 2020 02:33:12 +0000</pubDate>
	<author>corn81jaw</author>
	<category>News</category>
	<votes>1</votes>
	<guid>https://slavyanski.net/sb2020/story.php?title=assessment-of-the-bioactivity-of-adalimumab-should-include-assessment-of-multiple-7</guid>
</item>

<item>
	<title><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity]]></title>
	<link>https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-3</link>
	<source url="https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-3"><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity]]></source>
	<description><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity to clinical efficacy is unclear, it is important to characterize all activities of the candidate mAb, especially those that can be affected by differences in post-translational modifications, such as glycosylation. The ability of ABP 501 to induce ADCC was assessed using MT-3 cells as target cells, and NK-92M1 cells s ]]></description>
	<pubDate>Tue, 18 Aug 2020 02:30:06 +0000</pubDate>
	<author>corn81jaw</author>
	<category></category>
	<votes>1</votes>
	<guid>https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-3</guid>
</item>

<item>
	<title><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity]]></title>
	<link>https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-1</link>
	<source url="https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-1"><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity]]></source>
	<description><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity to clinical efficacy is unclear, it is important to characterize all activities of the candidate mAb, especially those that can be affected by differences in post-translational modifications, such as glycosylation. The ability of ABP 501 to induce ADCC was assessed using MT-3 cells as target cells, and NK-92M1 cells s ]]></description>
	<pubDate>Tue, 18 Aug 2020 02:29:37 +0000</pubDate>
	<author>corn81jaw</author>
	<category>News</category>
	<votes>1</votes>
	<guid>https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-1</guid>
</item>

<item>
	<title><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity]]></title>
	<link>https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-9</link>
	<source url="https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-9"><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity]]></source>
	<description><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity to clinical efficacy is unclear, it is important to characterize all activities of the candidate mAb, especially those that can be affected by differences in post-translational modifications, such as glycosylation. The ability of ABP 501 to induce ADCC was assessed using MT-3 cells as target cells, and NK-92M1 cells s ]]></description>
	<pubDate>Wed, 12 Aug 2020 05:02:04 +0000</pubDate>
	<author>corn81jaw</author>
	<category></category>
	<votes>1</votes>
	<guid>https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-9</guid>
</item>

<item>
	<title><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity]]></title>
	<link>https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-2</link>
	<source url="https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-2"><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity]]></source>
	<description><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity to clinical efficacy is unclear, it is important to characterize all activities of the candidate mAb, especially those that can be affected by differences in post-translational modifications, such as glycosylation. The ability of ABP 501 to induce ADCC was assessed using MT-3 cells as target cells, and NK-92M1 cells s ]]></description>
	<pubDate>Wed, 12 Aug 2020 05:01:32 +0000</pubDate>
	<author>corn81jaw</author>
	<category></category>
	<votes>1</votes>
	<guid>https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-2</guid>
</item>

<item>
	<title><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity]]></title>
	<link>https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-6</link>
	<source url="https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-6"><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity]]></source>
	<description><![CDATA[To mediate ADCC in vitro [9, 17, 23]. Although the contribution of ADCC activity to clinical efficacy is unclear, it is important to characterize all activities of the candidate mAb, especially those that can be affected by differences in post-translational modifications, such as glycosylation. The ability of ABP 501 to induce ADCC was assessed using MT-3 cells as target cells, and NK-92M1 cells s ]]></description>
	<pubDate>Fri, 07 Aug 2020 08:15:12 +0000</pubDate>
	<author>corn81jaw</author>
	<category>News</category>
	<votes>1</votes>
	<guid>https://slavyanski.net/sb2020/story.php?title=to-mediate-adcc-in-vitro-9-17-23-although-the-contribution-of-adcc-activity-6</guid>
</item>

<item>
	<title><![CDATA[T assays were conducted, and the mean percent relative activity is]]></title>
	<link>https://slavyanski.net/sb2020/story.php?title=t-assays-were-conducted-and-the-mean-percent-relative-activity-is-2</link>
	<source url="https://slavyanski.net/sb2020/story.php?title=t-assays-were-conducted-and-the-mean-percent-relative-activity-is-2"><![CDATA[T assays were conducted, and the mean percent relative activity is]]></source>
	<description><![CDATA[T assays were conducted, and the mean percent relative activity is reported (see text). A dose response from a single assay of the three is presented here as representative data. e Representative nonconstrained dose?response curves of ABP 501 (red), adalimumab (US) (black), and adalimumab (EU) (blue) showing binding to FcRn. Each point is a mean of three replicates ?standard deviation. Adalimumab  ]]></description>
	<pubDate>Fri, 07 Aug 2020 07:55:35 +0000</pubDate>
	<author>corn81jaw</author>
	<category></category>
	<votes>1</votes>
	<guid>https://slavyanski.net/sb2020/story.php?title=t-assays-were-conducted-and-the-mean-percent-relative-activity-is-2</guid>
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