In 363, less than the terms of a peace treaty, Nisibis was ceded to the Persians, resulting in Ephrem the Syrian, accompanied by a number of lecturers, to go away the School of Nisibis for Edessa nevertheless in Roman territory. He was in favour with the Emperor Justinian, who used him in the imperial services and sent him to Asia Minor to preach amongst the pagans nevertheless to be observed round Ephesus.