Premature ovarian failure (POF), or early menopause, is a acknowledged complication of trisomy X. Premature ovarian failure is described as menopause before the age of 40 in the basic population, one in one hundred women of all ages expertise menopause prior to this age, 1 in 1,000 prior to age 30, and 1 in 10,000 ahead of age 20. Amongst girls with POF, 3% have trisomy X, compared to one in 1,000 in the general inhabitants.