In 363, less than the phrases of a peace treaty, Nisibis was ceded to the Persians, resulting in Ephrem the Syrian, accompanied by a selection of instructors, to depart the School of Nisibis for Edessa still in Roman territory. He was in favour with the Emperor Justinian, who utilized him in the imperial company and despatched him to Asia Minor to preach amongst the pagans still to be discovered round Ephesus.